Constitutive Activation of Transcription Factor NF-KappaB in Multiple Sclerosis
| المؤلف الرئيسي: | Al Slail, Maryam (Author) |
|---|---|
| مؤلفين آخرين: | Yan, Jun (Advisor) |
| التاريخ الميلادي: |
2010
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| موقع: | بريزبن |
| الصفحات: | 1 - 28 |
| رقم MD: | 753064 |
| نوع المحتوى: | رسائل جامعية |
| اللغة: | الإنجليزية |
| الدرجة العلمية: | رسالة ماجستير |
| الجامعة: | Queensland University |
| الكلية: | School of Medicine |
| الدولة: | أستراليا |
| قواعد المعلومات: | +Dissertations |
| مواضيع: | |
| رابط المحتوى: |
الناشر لهذه المادة لم يسمح بإتاحتها. |
| المستخلص: |
Introduction: Multiple sclerosis (MS) is an autoimmune disease that influences the central nervous system (CNS). It has three major clinical subtypes: Relapsing–remitting (RR-MS), secondary progressive (SP-MS) and primary progressive (PP-MS). MS pathogenesis has not been found yet, but it is believed that the nuclear factor kappa B (NF-B) plays an important role in MS development. Because of the Role that NF-B plays in MS pathogenesis, we examined p65 and p50 in order to understand its constitutive activation in PBMC of patients with MS. Method: Two NF-B members (p65, p50) had been investigated in this study using double staining immunofluorescence and immunohistochemistry techniques. Ten subjects from each MS clinical group and 10 healthy controls had been examined for their nuclear translocation in PBMC. Results: p65 nuclear translocation has been observed to be increased in CD8 T cells and CD68 monocytes in progressive MS. p65 nuclear translocation in RR-MS has also shown an increase in CD8 T cell, CD 4 T cells and CD20 B cells. The nuclear translocation of p50 showed different trend. Conclusion: The NF-B p65 activation is increased in progressive MS compared to healthy controls. This is due to the translocation of p65 from the cytoplasm to the nucleus of the cells. P50 did not show such translocation. |
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