In vitro Norepinephrine & Dopamine decrease Circulating Haemopoietic CFU-GM
| المصدر: | مجلة الأستاذ |
|---|---|
| الناشر: | جامعة طرابلس - نقابة أعضاء هيئة التدريس |
| المؤلف الرئيسي: | Afan, Ali M. (Author) |
| مؤلفين آخرين: | Abusaida, Hana M. (Co-Author) , Annajar, Mahmoud S. (Co-Author) |
| المجلد/العدد: | ع7 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2014
|
| الشهر: | خريف |
| الصفحات: | 23 - 30 |
| رقم MD: | 851077 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | EduSearch |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
9
| المستخلص: |
The mechanisms mediating hematopoietic stem and progenitor cell (HSPC) mobilization are complex. A recent study showed that hematopoietic colony forming capacity/functionality under the autonomic nervous system. Herein we investigated whether norepinephrine (NE) and dopamine (DA) concentration could be responsible for directly influencing granulocyte-macrophage colony forming unit (CFU-GM) functionality. Bone marrow cells were taken from femora of healthy male mice (6- 12 weeks old). The influence of NE and DA on marrow CFU-GM was analyzed in vitro under normal appropriate granulocyte-macrophage colony forming unit (CFU-GM) assays. Specific concentrations (10'8 M) of free NE, DA showed a significant impairment of growing CFU-GM. Thus, NE and DA were thought to trigger CFU-GM mobilization and proliferation capacity suggesting that high concentration of both NE and DA have a direct negative effect on mobilization of marrow cellularity. Furthermore, results also show that beta and alpha -adrenergic antagonists such as propranolol and prazosin could directly counter-act the effect of NE on GM-CFU. |
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