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02010nam a22002537a 4500 |
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1606283 |
| 041 |
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|a eng
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| 044 |
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|b ليبيا
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| 100 |
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|9 457377
|a Afan, Ali M.
|e Author
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| 245 |
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|a In vitro Norepinephrine & Dopamine decrease Circulating Haemopoietic CFU-GM
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| 260 |
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|b جامعة طرابلس - نقابة أعضاء هيئة التدريس
|c 2014
|g خريف
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| 300 |
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|a 23 - 30
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| 336 |
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|a بحوث ومقالات
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| 520 |
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|b The mechanisms mediating hematopoietic stem and progenitor cell (HSPC) mobilization are complex. A recent study showed that hematopoietic colony forming capacity/functionality under the autonomic nervous system. Herein we investigated whether norepinephrine (NE) and dopamine (DA) concentration could be responsible for directly influencing granulocyte-macrophage colony forming unit (CFU-GM) functionality. Bone marrow cells were taken from femora of healthy male mice (6- 12 weeks old). The influence of NE and DA on marrow CFU-GM was analyzed in vitro under normal appropriate granulocyte-macrophage colony forming unit (CFU-GM) assays. Specific concentrations (10'8 M) of free NE, DA showed a significant impairment of growing CFU-GM. Thus, NE and DA were thought to trigger CFU-GM mobilization and proliferation capacity suggesting that high concentration of both NE and DA have a direct negative effect on mobilization of marrow cellularity. Furthermore, results also show that beta and alpha -adrenergic antagonists such as propranolol and prazosin could directly counter-act the effect of NE on GM-CFU.
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| 653 |
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|a فصائل الدم
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| 653 |
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|a تحليل الدم
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| 653 |
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|a الأمراض الدموية
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| 700 |
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|9 457378
|a Abusaida, Hana M.
|e Co-Author
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| 700 |
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|9 457379
|a Annajar, Mahmoud S.
|e Co-Author
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| 773 |
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|4 التربية والتعليم
|6 Education & Educational Research
|c 013
|e Al-OstaTh
|l 007
|m ع7
|o 1594
|s مجلة الأستاذ
|v 000
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| 856 |
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|u 1594-000-007-013.pdf
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| 930 |
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|d y
|p y
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| 995 |
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|a EduSearch
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| 999 |
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|c 851077
|d 851077
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