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Effect Curcumin Plant on Liver of Rats Treated with Trichloethylene

المصدر: مجلة التربوي
الناشر: جامعة المرقب - كلية التربية بالخمس
المؤلف الرئيسي: الغويج، ليلى منصور عطية (مؤلف)
مؤلفين آخرين: الطرابلسي، زهرة بشير (م. مشارك)
المجلد/العدد: ع12
محكمة: نعم
الدولة: ليبيا
التاريخ الميلادي: 2018
الشهر: يناير
الصفحات: 321 - 328
ISSN: 2011-421X
رقم MD: 879496
نوع المحتوى: بحوث ومقالات
اللغة: الإنجليزية
قواعد المعلومات: EduSearch
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المستخلص: Background & Aims: Curcumin (CCM), a plant phenolic compound, is widely used as a spice and coloring agent in food. Recently, CCM, had been considered to possess antioxidant activities. This study aimed to investigate whether CCM, protect against trichloroethylene (TCE)- induced hepatotoxicity and to demonstrate its possible mode of action. Methods: A group of male rats were treated with TCE (5mg/1000 ml of drinking water) to induce liver injury. The CCM group was fed 25 g mixed with the diet (2.5Kg) concomitantly with 5 mg TCE/1000ml drinking water, for 8 weeks. The rat were killed after treatment period of 8 weeks, and samples of livers tissue were fixed immediately in 10% formalin. Results: Histopathological changes It was obviose that TCE administration has shown dramatic injures in the liver tissues, and the treatment with curcumin can activate these injures to advanced level.

ISSN: 2011-421X

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