Effect of Captopril on Paracetamol Induced nephrotoxicity in Rats : Histological study
| المصدر: | الجنان |
|---|---|
| الناشر: | جامعة الجنان - مركز البحث العلمي |
| المؤلف الرئيسي: | Al-Shaikh, Turki M. (Author) |
| مؤلفين آخرين: | Mudawi, Mahmoud M. E. (Co-Author), Ayiad, Reem (Co-Author), Yassin, Abdelhadi Y. A. (Co-Author), Habeballa, Rami S. (Co-Author) |
| المجلد/العدد: | ع10 |
| محكمة: | نعم |
| الدولة: |
لبنان |
| التاريخ الميلادي: |
2018
|
| الصفحات: | 449 - 474 |
| DOI: |
10.33986/0522-000-010-020 |
| ISSN: |
2308-0671 |
| رقم MD: | 891700 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | IslamicInfo |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
5
| المستخلص: |
Paracetamol)is widely used without prescription as an over the counter (OTC) dru). Many studies reported that it can cause renal toxicity unlike ACE inhibitors like Captopril)that can have renal protective effects. Since many patients may take Paracetamol and Captopril concomitantl , the aim of this study is to evaluate the renal protective effect of Captopril on Paracetamolinduced nephrotoxicity. The present study was conducted in two phases. Phase (1): high dose Paracetamol: Animals were divided into 4 groups of 6 rats each. Group 1 (control group), Group 2 (Paracetamol 3000 mg/kg group) and Group 3 (Captopril 20 mg/kg group) were pretreated orally with 0.9 % normal saline consecutively for 7 days; Group 4 (Captopril + Paracetamol group) was pretreated with Captopril 20 mg/kg consecutively for 7 days. After 24 hours (on day 8), group 1 administered 0.9 % normal saline, whereas group 2 (paracetamol) and group 4 (Captopril + Paracetamol) administered single oral dose of Paracetamol 3000 mg/kg; group 3 administered captopril 20 mg/kg. Rats were then sacrificed and the kidneys were dissected for histopathological studies. Phase (2): low dose paracetamol: Rats were divided into 4 groups of 6 rats each. Group 1: was treated orally with 0.9% normal saline, Group 2: received paracetamol (300 mg/kg), Group 3: administered captopril (20 mg/ |
|---|---|
| ISSN: |
2308-0671 |
عناصر مشابهة
-
Biochemical Studies on the Effect of Ecballium Elaterium Fruit Juice as an Antioxidant against Hepatotoxicity Induced by Paracetamol
بواسطة: Muftah, Saleh M. A. منشور: (2013) -
Protective Role of the Combination of Resveratrol and N-Acetylcysteine in Preventing Acute Paracetamol-Induced Nephropathy in Rats
بواسطة: شاطي، علي عبدالله منشور: (2018) -
Antioxidant and Hepato protective Effect of Some Sudanese Medicinal Plants on Paracetamol – Induced Hepatotoxicity
بواسطة: Abd Al Gader, Nadia Nour Eldin منشور: (2013) -
The antimutagenic effect of coumarin on sister chromatid exchange induced by paracetamol and mitomycin C.in cultures human Lymphocytes
بواسطة: Atrooz, Fatin Y. منشور: (1999) -
Protection From the Acute Cisplatin-Induced Nephrotoxicity By Eruca Sativa Seed Oil and Simvastatin in Rats
بواسطة: Hasan, Ahsan Falah منشور: (2011)
