Effect of Captopril on Paracetamol Induced nephrotoxicity in Rats : Histological study
| المصدر: | الجنان |
|---|---|
| الناشر: | جامعة الجنان - مركز البحث العلمي |
| المؤلف الرئيسي: | Al-Shaikh, Turki M. (Author) |
| مؤلفين آخرين: | Mudawi, Mahmoud M. E. (Co-Author) , Ayiad, Reem (Co-Author) , Yassin, Abdelhadi Y. A. (Co-Author) , Habeballa, Rami S. (Co-Author) |
| المجلد/العدد: | ع10 |
| محكمة: | نعم |
| الدولة: |
لبنان |
| التاريخ الميلادي: |
2018
|
| الصفحات: | 449 - 474 |
| DOI: |
10.33986/0522-000-010-020 |
| ISSN: |
2308-0671 |
| رقم MD: | 891700 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | IslamicInfo |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
5
| المستخلص: |
Paracetamol)is widely used without prescription as an over the counter (OTC) dru). Many studies reported that it can cause renal toxicity unlike ACE inhibitors like Captopril)that can have renal protective effects. Since many patients may take Paracetamol and Captopril concomitantl , the aim of this study is to evaluate the renal protective effect of Captopril on Paracetamolinduced nephrotoxicity. The present study was conducted in two phases. Phase (1): high dose Paracetamol: Animals were divided into 4 groups of 6 rats each. Group 1 (control group), Group 2 (Paracetamol 3000 mg/kg group) and Group 3 (Captopril 20 mg/kg group) were pretreated orally with 0.9 % normal saline consecutively for 7 days; Group 4 (Captopril + Paracetamol group) was pretreated with Captopril 20 mg/kg consecutively for 7 days. After 24 hours (on day 8), group 1 administered 0.9 % normal saline, whereas group 2 (paracetamol) and group 4 (Captopril + Paracetamol) administered single oral dose of Paracetamol 3000 mg/kg; group 3 administered captopril 20 mg/kg. Rats were then sacrificed and the kidneys were dissected for histopathological studies. Phase (2): low dose paracetamol: Rats were divided into 4 groups of 6 rats each. Group 1: was treated orally with 0.9% normal saline, Group 2: received paracetamol (300 mg/kg), Group 3: administered captopril (20 mg/ |
|---|---|
| ISSN: |
2308-0671 |
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