The Role of Hydroxyurea in Management of Sickle Cell Anaemia
| المؤلف الرئيسي: | Oun, Tahani Ibrahim Ali (Author) |
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| مؤلفين آخرين: | Gamereldeen, Eltayeb Mohamed Eltayeb (Advisor) |
| التاريخ الميلادي: |
2015
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| موقع: | ام درمان |
| الصفحات: | 1 - 35 |
| رقم MD: | 913498 |
| نوع المحتوى: | رسائل جامعية |
| اللغة: | الإنجليزية |
| الدرجة العلمية: | رسالة ماجستير |
| الجامعة: | جامعة أم درمان الاسلامية |
| الكلية: | كلية الصيدلة |
| الدولة: | السودان |
| قواعد المعلومات: | Dissertations |
| مواضيع: | |
| رابط المحتوى: |
عدد مرات التحميل
28
| المستخلص: |
Sickle cell anemia results from the replacement of the amino acid “glutamic” by “valine” on the 6 position on the Beta chain. This results in the crystallization of haemoglobin, rigidity of the cell and development of haemolytic anaemia and impairment in the function of some organs. Aim: To high light the benefit of the administration of Hydorxyurea as a first choice in the management of sickle cell anaemia usually in the severe cases. Materials and methods: Anticoagulated specimens were collected. Screen test and solubility test were carried out. On positive results Hb – electrophoresis was applied to differentiate between sickle cell trait (A/S) and sickle cell disease (S/S). In patient with severe sickle cell anaemia Hydroxyurea was administrated. Hb – F level was done pre and post treatment to evaluate the response of the drug. The results showed that Hb – F level was significantly elevated (P ≤ 0.001) after treatment with Hydroxyuea and will give protection to red cells containing Hb – S. This study concluded that, Hydroxyurea increases markedly the level of Hb – F consequently protect the red cell against sickling phenomenon, thus increases life span of red cells. |
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