| LEADER |
02641nam a22003257a 4500 |
| 001 |
1489916 |
| 041 |
|
|
|a eng
|
| 100 |
|
|
|9 489716
|a Oun, Tahani Ibrahim Ali
|e Author
|
| 245 |
|
|
|a The Role of Hydroxyurea in Management of Sickle Cell Anaemia
|
| 260 |
|
|
|a ام درمان
|c 2015
|
| 300 |
|
|
|a 1 - 35
|
| 336 |
|
|
|a رسائل جامعية
|
| 502 |
|
|
|b رسالة ماجستير
|c جامعة أم درمان الاسلامية
|f كلية الصيدلة
|g السودان
|o 0198
|
| 520 |
|
|
|a Sickle cell anemia results from the replacement of the amino acid “glutamic” by “valine” on the 6 position on the Beta chain. This results in the crystallization of haemoglobin, rigidity of the cell and development of haemolytic anaemia and impairment in the function of some organs. Aim: To high light the benefit of the administration of Hydorxyurea as a first choice in the management of sickle cell anaemia usually in the severe cases. Materials and methods: Anticoagulated specimens were collected. Screen test and solubility test were carried out. On positive results Hb – electrophoresis was applied to differentiate between sickle cell trait (A/S) and sickle cell disease (S/S). In patient with severe sickle cell anaemia Hydroxyurea was administrated. Hb – F level was done pre and post treatment to evaluate the response of the drug. The results showed that Hb – F level was significantly elevated (P ≤ 0.001) after treatment with Hydroxyuea and will give protection to red cells containing Hb – S. This study concluded that, Hydroxyurea increases markedly the level of Hb – F consequently protect the red cell against sickling phenomenon, thus increases life span of red cells.
|
| 653 |
|
|
|a فقر الدم المنجلي
|a الهيدروكسي يوريا
|a تخثر الدم
|a الخلايا المنجلية
|a الوقاية والعلاج
|
| 700 |
|
|
|9 462121
|a Gamereldeen, Eltayeb Mohamed Eltayeb
|e Advisor
|
| 856 |
|
|
|u 9818-003-016-0198-T.pdf
|y صفحة العنوان
|
| 856 |
|
|
|u 9818-003-016-0198-A.pdf
|y المستخلص
|
| 856 |
|
|
|u 9818-003-016-0198-C.pdf
|y قائمة المحتويات
|
| 856 |
|
|
|u 9818-003-016-0198-F.pdf
|y 24 صفحة الأولى
|
| 856 |
|
|
|u 9818-003-016-0198-1.pdf
|y 1 الفصل
|
| 856 |
|
|
|u 9818-003-016-0198-2.pdf
|y 2 الفصل
|
| 856 |
|
|
|u 9818-003-016-0198-3.pdf
|y 3 الفصل
|
| 856 |
|
|
|u 9818-003-016-0198-4.pdf
|y 4 الفصل
|
| 856 |
|
|
|u 9818-003-016-0198-O.pdf
|y الخاتمة
|
| 856 |
|
|
|u 9818-003-016-0198-R.pdf
|y المصادر والمراجع
|
| 856 |
|
|
|u 9818-003-016-0198-S.pdf
|y الملاحق
|
| 930 |
|
|
|d y
|
| 995 |
|
|
|a Dissertations
|
| 999 |
|
|
|c 913498
|d 913498
|
