Synyhesis and Reaction Mechanism of Some Compounds Re Lated To Furo[2,3-D][Pyrimidines And Pyrimido[4\\,5\\; 4,5 ]Furo[2,3 D][Pyrimidines
| المصدر: | مجلة العلوم الإنسانية والتطبيقية |
|---|---|
| الناشر: | الجامعة الأسمرية الإسلامية زليتن - كليتى الآداب والعلوم |
| المؤلف الرئيسي: | Mussa, Suliman M. (Author) |
| المجلد/العدد: | ع29 |
| محكمة: | نعم |
| الدولة: |
ليبيا |
| التاريخ الميلادي: |
2016
|
| الشهر: | ديسمبر |
| الصفحات: | 122 - 148 |
| رقم MD: | 829543 |
| نوع المحتوى: | بحوث ومقالات |
| اللغة: | الإنجليزية |
| قواعد المعلومات: | HumanIndex |
| مواضيع: | |
| كلمات المؤلف المفتاحية: |
Synthesis | Reaction Mechanism | Furo[2,3-D]Pyrimidine | Pyrimido[4\,5\:4,5]Furo[2,3-D]Pyrimidine | Spectral Characteristics
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| رابط المحتوى: |
عدد مرات التحميل
4
| المستخلص: |
Ethyl 5-amino-4-methyl-2-phenylfuro[2,3-d]pyrimidine–6-carboxylate (1) was used as precursor for the synthesis of pyrimido furoppyrimidines 2 , 3 and fur pyrimidine derivative4 by reaction withphenyl isothiocyanate , form amide and hydrazine hydrate respectively .Also Saponification of compound 1 followed by treatment with orthophosphoric acid afforded compound6 which underwent condensation with 4- methoxybenzaldehyde to give 6-arylidene-4-methyl-2-phenylfuro[2,3-d]pyrimidin-5- one(7) . On the other hand refluxing of compound 5 with acetic anhydride gave 5- N,Ndiacetylamino)- 4-methyl-2-phenylfuro[2,3-d]pyrimidine (9), which on treatment with hydrazine hydrate afforded N-acetyl amino derivative 10 .Chlorination of compound 3 with phosphorus oxychloride gave 8-Chloro-4-methyl-2-phenylpyrimido[4,5:4,5]furo[2,3-d]pyrimidine (11),which up on treatment with hydrazine hydrate gave the corresponding hydrazine derivatives 12. Condensation of compound 4 with 4-nitrobenzaldehydes gave 5- Amino-6-(4-nitrobenzylidene)-4-methyl-2-phenylfuro[2,3-d]pyrimidine-6-carbohydrazone (13).On the other hand refluxing of carbohydrazide 4 with formic acid and acetic anhydride led to the formation of compounds 14 and 15 respectively. Also 3,5-dimethyl parazolyl derivative 16 was prepared from the reaction of compound 4 with acetyl acetone . Treatment of compound1with 2,5-dimethoxytetrahydrofuran produced the compound17,which reacted with hydrazine hydrate to give carbohydrazide derivative18. The reaction of 18 with CS2followed by methyl iodide gave the 6-(2-methylthio-1,3,4-oxadiazol-5-yl)-4-methyl-5-(1-pyrrolyl)-2-phenylfuro[2,3-d]pyrimidine ( 20 ). On the other handcompounds21 and 22 were obtained by the condensation of compound 20 with morpholine and 1,2,3,4-tetrahydroquinoline respectively . |
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عناصر مشابهة
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Synthesi and Reaction Mechanism of Some Compounds Realated to Thie No " 2,3-D " Pyrimidine Moiety
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Synthesis and Biological Activity of Some New 2-(2,4 dimethoxyphenylpyrrolo [2,3-d] Pyrimidine Compounds
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Synthesis and Properties of some New Chiral 7'- (Substituted) Benzofurylpyrazolo [4, 3-d] Pyrimidin -7- Ones
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Synthesis of 2,4-Disubstituted-6,7-Dihydro-5H- Cyclopenta "4,5" Thieno "2,3-D" Pyrimidine Derivatives as Potential Antiinflammatory Agents
بواسطة: سلو، ربى أنور منشور: (2020)
