| LEADER |
02930nam a22002177a 4500 |
| 001 |
1587886 |
| 041 |
|
|
|a eng
|
| 044 |
|
|
|b ليبيا
|
| 100 |
|
|
|9 433462
|a Mussa, Suliman M.
|e Author
|
| 245 |
|
|
|a Synyhesis and Reaction Mechanism of Some Compounds Re Lated To Furo[2,3-D][Pyrimidines And Pyrimido[4\\,5\\; 4,5 ]Furo[2,3 D][Pyrimidines
|
| 260 |
|
|
|b الجامعة الأسمرية الإسلامية زليتن - كليتى الآداب والعلوم
|c 2016
|g ديسمبر
|
| 300 |
|
|
|a 122 - 148
|
| 336 |
|
|
|a بحوث ومقالات
|b Article
|
| 520 |
|
|
|b Ethyl 5-amino-4-methyl-2-phenylfuro[2,3-d]pyrimidine–6-carboxylate (1) was used as precursor for the synthesis of pyrimido furoppyrimidines 2 , 3 and fur pyrimidine derivative4 by reaction withphenyl isothiocyanate , form amide and hydrazine hydrate respectively .Also Saponification of compound 1 followed by treatment with orthophosphoric acid afforded compound6 which underwent condensation with 4- methoxybenzaldehyde to give 6-arylidene-4-methyl-2-phenylfuro[2,3-d]pyrimidin-5- one(7) . On the other hand refluxing of compound 5 with acetic anhydride gave 5- N,Ndiacetylamino)- 4-methyl-2-phenylfuro[2,3-d]pyrimidine (9), which on treatment with hydrazine hydrate afforded N-acetyl amino derivative 10 .Chlorination of compound 3 with phosphorus oxychloride gave 8-Chloro-4-methyl-2-phenylpyrimido[4\,5\:4,5]furo[2,3-d]pyrimidine (11),which up on treatment with hydrazine hydrate gave the corresponding hydrazine derivatives 12. Condensation of compound 4 with 4-nitrobenzaldehydes gave 5- Amino-6-(4-nitrobenzylidene)-4-methyl-2-phenylfuro[2,3-d]pyrimidine-6-carbohydrazone (13).On the other hand refluxing of carbohydrazide 4 with formic acid and acetic anhydride led to the formation of compounds 14 and 15 respectively. Also 3,5-dimethyl parazolyl derivative 16 was prepared from the reaction of compound 4 with acetyl acetone . Treatment of compound1with 2,5-dimethoxytetrahydrofuran produced the compound17,which reacted with hydrazine hydrate to give carbohydrazide derivative18. The reaction of 18 with CS2followed by methyl iodide gave the 6-(2-methylthio-1,3,4-oxadiazol-5-yl)-4-methyl-5-(1-pyrrolyl)-2-phenylfuro[2,3-d]pyrimidine ( 20 ). On the other handcompounds21 and 22 were obtained by the condensation of compound 20 with morpholine and 1,2,3,4-tetrahydroquinoline respectively .
|
| 653 |
|
|
|a المعادلات الكيميائية
|a التفاعلات الكيميائية
|
| 692 |
|
|
|b Synthesis
|b Reaction Mechanism
|b Furo[2,3-D]Pyrimidine
|b Pyrimido[4\,5\:4,5]Furo[2,3-D]Pyrimidine
|b Spectral Characteristics
|
| 773 |
|
|
|4 العلوم الإنسانية ، متعددة التخصصات
|6 Humanities, Multidisciplinary
|c 031
|l 029
|m ع29
|o 1582
|s مجلة العلوم الإنسانية والتطبيقية
|t Journal of Humanities and Applied Sciences
|v 000
|
| 856 |
|
|
|u 1582-000-029-031.pdf
|
| 930 |
|
|
|d y
|p y
|q n
|
| 995 |
|
|
|a HumanIndex
|
| 999 |
|
|
|c 829543
|d 829543
|
